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Papers of the Week

Papers: 12 Mar 2022 - 18 Mar 2022

Pharmacology/Drug Development


2022 Mar 10

J Allergy Clin Immunol

Mast cells, cortistatin, and its receptor, MRGPRX2, are linked to the pathogenesis of chronic prurigo.


Kolkhir P, Pyatilova P, Ashry T, Jiao Q, Abad-Perez A T, Altrichter S, Vera Ayala C E, Church MK, He J, Lohse K, Metz M, Scheffel J, Türk M, Frischbutter S, Maurer M
J Allergy Clin Immunol. 2022 Mar 10.
PMID: 35283140.


Chronic prurigo (CPG) is characterized by intensive itch and nerve-neuropeptide-mast cell interactions. The role of some neuropeptides such as cortistatin and its receptor MRGPRX2 in CPG is poorly investigated.