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Papers of the Week

2022 Mar-Apr

In Vivo



Antidepressant Fluoxetine Does Not Appear to Interfere With Key Translational Parameters in the Rat Adjuvant-induced Arthritis Model.


Seveljevic-Jaran D, Kalliokoski O, Abelson KSP, Hau J
In Vivo. 2022 Mar-Apr; 36(2):635-642.
PMID: 35241516.


This study aimed to investigate the analgesic effects of fluoxetine on Lewis rats of both sexes in the adjuvant-induced arthritis (AIA) rat model. In humans, chronic pain syndromes typical of rheumatoid arthritis (RA) co-exist with depression which is often treated with fluoxetine antidepressant known to have antinociceptive effects.