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Papers of the Week

2022 Feb 19

BMC Bioinformatics



Using amino acids co-occurrence matrices and explainability model to investigate patterns in dengue virus proteins.


Souza LR, Colonna JG, Comodaro JM, Naveca FG
BMC Bioinformatics. 2022 Feb 19; 23(1):80.
PMID: 35183126.


Dengue is a common vector-borne disease in tropical countries caused by the Dengue virus. This virus may trigger a disease with several symptoms like fever, headache, nausea, vomiting, and muscle pain. Indeed, dengue illness may also present more severe and life-threatening conditions like hemorrhagic fever and dengue shock syndrome. The causes that lead hosts to develop severe infections are multifactorial and not fully understood. However, it is hypothesized that different viral genome signatures may partially contribute to the disease outcome. Therefore, it is plausible to suggest that deeper DENV genetic information analysis may bring new clues about genetic markers linked to severe illness.