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Papers of the Week

2022 Feb 17

Z Gastroenterol

Whipple’s disease – a rare and challenging complication in a patient with Crohn’s disease.


Bulut K, Markova A, Canbay AE, Schmidt WE, Kahraman A
Z Gastroenterol. 2022 Feb 17.
PMID: 35176806.


Whipple's disease (WD) is a rare and infectious condition leading to multi-organ impairment caused by Tropheryma whipplei (TW), a ubiquitously occurring bacterium. TW can be detected in tissues by histological detection of PAS ("periodic acid-ship reaction")-positive macrophages and by polymerase-chain-reaction (PCR). Clinically, WD is often characterized by diarrhea, abdominal pain, and weight loss. These symptoms are also typical for a flare in Crohn's disease (CD) and, therefore, can lead to fatal misdiagnosis and wrong treatment by using biologics (e.g., anti-TNF-α).