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Papers of the Week

Papers: 12 Feb 2022 - 18 Feb 2022

Pharmacology/Drug Development

2022 Feb 15


Patient-Centered Treatment of Chronic Migraine With Medication Overuse: A Prospective, Randomized, Pragmatic Clinical Trial.


Schwedt T, Hentz J, Sahai-Srivastava S, Murinova N, Spare N, Treppendahl C, Martin VT, Birlea M, Digre K, Watson D, Leonard M, Robert T, Dodick D
Neurology. 2022 Feb 15.
PMID: 35169011.


Overuse of symptomatic (i.e. acute) medications is common amongst those with chronic migraine. It is associated with developing frequent headaches, medication side effects, and reduced quality of life. The optimal treatment strategy for patients with chronic migraine with medication overuse (CMMO) has long been debated. The study objective was to determine if migraine preventive therapy switching or limiting the frequency of the overused medication was non-inferior to migraine preventive therapy switching from the overused medication to an alternate medication that could be used on 2 days/week.