I am a
Home I AM A Search Login

Papers of the Week


Papers: 12 Feb 2022 - 18 Feb 2022


Pharmacology/Drug Development


2022 Feb 15


Neurology

Patient-Centered Treatment of Chronic Migraine With Medication Overuse: A Prospective, Randomized, Pragmatic Clinical Trial.

Authors

Schwedt T, Hentz J, Sahai-Srivastava S, Murinova N, Spare N, Treppendahl C, Martin VT, Birlea M, Digre K, Watson D, Leonard M, Robert T, Dodick D
Neurology. 2022 Feb 15.
PMID: 35169011.

Abstract

Overuse of symptomatic (i.e. acute) medications is common amongst those with chronic migraine. It is associated with developing frequent headaches, medication side effects, and reduced quality of life. The optimal treatment strategy for patients with chronic migraine with medication overuse (CMMO) has long been debated. The study objective was to determine if migraine preventive therapy switching or limiting the frequency of the overused medication was non-inferior to migraine preventive therapy switching from the overused medication to an alternate medication that could be used on 2 days/week.