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Papers of the Week

2022 Feb 09

Mol Metab

ITCH E3 Ubiquitin Ligase downregulation compromises hepatic degradation of branched-chain amino acids.


Menghini R, Hoyles L, Cardellini M, Casagrande V, Marino A, Gentileschi P, Davato F, Mavilio M, Arisi I, Mauriello A, Montanaro M, Scimeca M, Barton RH, Rappa F, Cappello F, Vinciguerra M, Moreno-Navarrete J M, Ricart W, Porzio O, Fernández-Real J-M, et al.
Mol Metab. 2022 Feb 09:101454.
PMID: 35150905.


Metabolic syndrome, obesity and steatosis are characterized by a range of dysregulations including defects in ubiquitin ligase tagging proteins for degradation. The identification of novel hepatic genes associated with fatty liver disease and metabolic dysregulation may be relevant to unravel new mechanisms involved in liver disease progression.