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Papers of the Week

Papers: 5 Feb 2022 - 11 Feb 2022

2022 Feb 01

J Pain

The histamine-induced axon-reflex response in people with type 1 diabetes with and without peripheral neuropathy: A clinical, observational study.


Røikjer J, Croosu S S, Hansen T M, Frøkjær J B, Andersen H H, Arendt-Nielsen L, Mørch C D, Ejskjaer N
J Pain. 2022 Feb 01.
PMID: 35121142.


Small nerve fibres are important when studying diabetic peripheral neuropathy (DPN) as they could be first affected. However, assessing their integrity and function adequately remains a major challenge. The aim of this study was to investigate the association between different degrees of DPN, the presence of neuropathic pain (NP), and the intensity of the axon-reflex flare response provoked by epidermal histamine.