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Papers of the Week

Papers: 29 Jan 2022 - 4 Feb 2022

Human Studies


2022 Feb 03

Eur J Clin Invest

Increased serum diamine oxidase activity in non-allergic patients with migraine.


García-Martín E, Navarro-Muñoz S, Amo G, Rodriguez C, Serrador M, Alonso-Navarro H, Calleja M, Turpín-Fenoll L, Recio-Bermejo M, García-Ruiz R, Millán-Pascual J, Navacerrada F, Plaza-Nieto J F, García-Albea E, Agúndez JAG, Jiménez-Jiménez F J
Eur J Clin Invest. 2022 Feb 03:e13757.
PMID: 35113457.


Histamine has shown a possible role in the etiopathogenesis of migraine. It has been reported an association between some polymorphisms in the diamine oxidase (DAO) gene and migraine (specially in women). Two studies addressing DAO activity in migraine patients showed conflicting results. We investigated the possible relationship of serum DAO activity and histamine levels and 3 polymorphisms in the DAO gene with the risk for migraine.