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Papers of the Week

2021 Dec 25



Wuzhuyu Decoction relieves hyperalgesia by regulating central and peripheral 5-HT in chronic migraine model rats.


Nan N, Gong M-X, Wang Q, Li M-J, Xu R, Ma Z, Wang S-H, Zhao H, Xu Y-S
Phytomedicine. 2021 Dec 25; 96:153905.
PMID: 35026523.


Chronic migraine (CM) is a highly disabling and burdensome disease. Wuzhuyu decoction (WZYD), a clinical used formula to treat and prevent episodic migraine and CM, has been reported to relieve the hyperalgesia of CM and increase brainstem and blood serotonin (5-hydroxytryptamine, 5-HT) in migraine model rats in previous studies; yet the mechanism is unclear.