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Papers of the Week

Papers: 8 Jan 2022 - 14 Jan 2022

Pharmacology/Drug Development

2022 Jan 08

Life Sci

Olvanil activates sensory nerve fibers, increases T cell response and decreases metastasis of breast carcinoma.


Erin N, Akman M, Aliyev E, Tanrıöver G, Korcum AF
Life Sci. 2022 Jan 08:120305.
PMID: 35016880.


Inactivation of sensory neurons expressing transient receptor potential vanilloid 1 (TRPV1) enhances breast cancer metastasis. Sensory neurons have profound effects on immune response to a wide range of diseases including cancer. Hence, activation of sensory nerves using feasible approaches such as specific TRPV1 agonists may inhibit breast cancer metastasis through neuroimmune pathways. TRPV1 agonists are considered for the treatment of pain and inflammatory diseases.