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Papers of the Week

Papers: 18 Dec 2021 - 24 Dec 2021

Pharmacology/Drug Development

2021 Dec 21


Muscle function following testosterone replacement in men on opioid therapy for chronic non-cancer pain – a randomized controlled trial.


Kolind M I, Christensen L L, Caserotti P, Andersen M S, Glintborg D
Andrology. 2021 Dec 21.
PMID: 34933416.


Chronic pain and opioid treatment are associated with increased risk of male hypogonadism and subsequently decreased muscle function. A diagnosis of hypogonadism is based on the presence of low total testosterone (TT) and associated symptoms. The effect of testosterone replacement therapy (TRT) on muscle function in men with chronic pain and low TT remains to be investigated.