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Papers of the Week

Papers: 24 Jul 2021 - 30 Jul 2021

Human Studies

2021 Jul 29

Scand J Pain

Circulating long non-coding RNA signature in knee osteoarthritis patients with postoperative pain one-year after total knee replacement.


Giordano R, Petersen K K, Santoro M, Pazzaglia C, Simonsen O, Valeriani M, Arendt-Nielsen L
Scand J Pain. 2021 Jul 29.
PMID: 34323060.


The incidence of chronic postoperative pain after total knee replacement (TKR) is approx. 20%, and hence preoperative risk factors are important to identify. Recent studies have indicated that preoperative inflammatory markers might hold prognostic information for the development of chronic postoperative pain. Long non-coding RNA (lncRNA) regulates the expression of genes related to e.g. inflammatory processes. The current study aimed to investigate the preoperative lncRNA signature as possible preoperative predictive markers for chronic postoperative pain following TKR.