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Ther Adv Drug Saf


Tramadol-induced hiccups: a case-noncase study in the European pharmacovigilance database.


García M, Lertxundi U, Aguirre C
Ther Adv Drug Saf. 2021; 12:20420986211021230.
PMID: 34211690.


Hiccups are usually benign and self-limiting, but can sometimes be persistent. If left untreated, they can provoke severe discomfort, and even death. Hiccups can be idiopathic, organic, psychogenic, and caused by drugs. Although some case reports have suggested a possible association between tramadol and hiccups, to our knowledge, no study has analyzed this possible relationship. The aim of this study was to analyze whether a disproportionate number of cases of hiccups are reported for tramadol in the EudraVigilance database.