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Papers of the Week
Intracellular potassium depletion enhances apoptosis induced by staurosporine in cultured trigeminal satellite glial cells.
Abstract
Satellite glial cells (SGC) surrounding neurons in sensory ganglia can buffer extracellular potassium, regulating the excitability of injured neurons and possibly influencing a shift from acute to neuropathic pain. SGC apoptosis may be a key component in this process. This work evaluated induction or enhancement of apoptosis in cultured trigeminal SGC following changes in intracellular potassium [K]ic.