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Papers of the Week

2021 Jun 23

Expert Rev Neurother

Updated review on the link between cortical spreading depression and headache disorders.


Vuralli D, Karatas H, Yemisci M, Bolay H
Expert Rev Neurother. 2021 Jun 23.
PMID: 34162288.


Experimental animal studies have revealed mechanisms that link cortical spreading depression (CSD) to the trigeminal activation mediating lateralized headache. However, conventional CSD as seen in lissencephalic brain is insufficient to explain some clinical features of aura and migraine headache.