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Papers of the Week

Papers: 15 May 2021 - 21 May 2021

Human Studies, Pharmacology/Drug Development

2021 May 14

Psychopharmacology (Berl)

Evaluation of tradipitant, a selective NK1 antagonist, on response to oxycodone in humans.


Coe MA, Lofwall MR, Vessels V, Nuzzo PA, Walsh SL
Psychopharmacology (Berl). 2021 May 14.
PMID: 33988725.


Preclinical studies demonstrate that the NK1 receptor is involved in opioid reinforcement and withdrawal expression. Few studies have examined the impact of treatment with NK1 antagonists on opioid response in humans.