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Papers of the Week

Papers: 8 May 2021 - 14 May 2021

Human Studies

2021 May 13

Arthritis Rheumatol

Prediction of Differential Pharmacologic Response in Chronic Pain Using Functional Neuroimaging Biomarkers and Support Vector Machine Algorithm – An Exploratory Study.


Ichesco E, Peltier SJ, Mawla I, Harper DE, Pauer L, Harte SE, Clauw DJ, Harris RE
Arthritis Rheumatol. 2021 May 13.
PMID: 33982890.


There is increasing demand for prediction of chronic pain treatment outcomes using machine-learning models, in order to improve suboptimal pain management. In this exploratory study, we used baseline brain functional connectivity patterns from chronic pain patients suffering from Fibromyalgia (FM) to predict whether a patient would respond differentially to either milnacipran or pregabalin, two FDA-approved drugs for the treatment of FM.