I am a
Home I AM A Search Login

Papers of the Week

Papers: 1 May 2021 - 7 May 2021

Animal Studies

2021 May 06

J Neuroinflammation



Oxidative stress induced by NOX2 contributes to neuropathic pain via plasma membrane translocation of PKCε in rat dorsal root ganglion neurons.


Xu J, Wu S, Wang J, Wang J, Yan Y, Zhu M, Zhang D, Jiang C, Liu T
J Neuroinflammation. 2021 May 06; 18(1):106.
PMID: 33952299.


Nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2)-induced oxidative stress, including the production of reactive oxygen species (ROS) and hydrogen peroxide, plays a pivotal role in neuropathic pain. Although the activation and plasma membrane translocation of protein kinase C (PKC) isoforms in dorsal root ganglion (DRG) neurons have been implicated in multiple pain models, the interactions between NOX2-induced oxidative stress and PKC remain unknown.