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Papers: 1 May 2021 - 7 May 2021
2021 May 05
Neuron
109
9
How genetic loss of the sodium channel Na1.7 results in painlessness is puzzling. MacDonald et al. (2021) demonstrate that instead of impairing peripheral excitability, Na1.7 channels at central terminals of pain-sensing afferents play a pivotal role in the balance between pain and analgesia.