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Front Neurosci


Pain Relief Dependent on IL-17-CD4 T Cell-β-Endorphin Axis in Rat Model of Brachial Plexus Root Avulsion After Electroacupuncture Therapy.


Xu Z, Zhu Y, Shen J, Su L, Hou Y, Liu M, Jiao X, Chen X, Zhu S, Lu Y, Yao C, Wang L, Gong C, Ma Z, Zou C, Xu J
Front Neurosci. 2020; 14:596780.
PMID: 33633527.


Neuropathic pain is the typical symptom of brachial plexus root avulsion (BPRA), and no effective therapy is currently available. Electroacupuncture (EA), as a complementary and alternative therapy, plays a critical role in the management of pain-associated diseases. In the present study, we aimed to reveal the peripheral immunological mechanism of EA in relieving the pain of BPRA through the IL-17-CD4 T lymphocyte-β-endorphin axis.