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Papers of the Week

2021 Feb 04

BMC Pharmacol Toxicol



New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile.


Vasincu I-M, Apotrosoaei M, Constantin S, Butnaru M, Vereștiuc L, Lupușoru C-E, Buron F, Routier S, Lupașcu D, Taușer R-G, Profire L
BMC Pharmacol Toxicol. 2021 Feb 04; 22(1):10.
PMID: 33541432.


Aryl-propionic acid derivatives with ibuprofen as representative drug are very important for therapy, being recommended especially for anti-inflammatory and analgesic effects. On other hand 1,3-thiazolidine-4-one scaffold is an important heterocycle, which is associated with different biological effects such as anti-inflammatory and analgesic, antioxidant, antiviral, antiproliferative, antimicrobial etc. The present study aimed to evaluated the toxicity degree and the anti-inflammatory and analgesic effects of new 1,3-thiazolidine-4-one derivatives of ibuprofen.