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Papers of the Week

Papers: 30 Jan 2021 - 5 Feb 2021

Pharmacology/Drug Development

2021 Feb 03

Nat Rev Drug Discov

Trends in peptide drug discovery.


Muttenthaler M, King GF, Adams DJ, Alewood PF
Nat Rev Drug Discov. 2021 Feb 03.
PMID: 33536635.


Since the introduction of insulin almost a century ago, more than 80 peptide drugs have reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, multiple sclerosis, HIV infection and chronic pain. In this Perspective, we summarize key trends in peptide drug discovery and development, covering the early efforts focused on human hormones, elegant medicinal chemistry and rational design strategies, peptide drugs derived from nature, and major breakthroughs in molecular biology and peptide chemistry that continue to advance the field. We emphasize lessons from earlier approaches that are still relevant today as well as emerging strategies such as integrated venomics and peptide-display libraries that create new avenues for peptide drug discovery. We also discuss the pharmaceutical landscape in which peptide drugs could be particularly valuable and analyse the challenges that need to be addressed for them to reach their full potential.