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Papers of the Week

2021 Jan 28

Expert Rev Clin Pharmacol

Afamelanotide for prevention of phototoxicity in erythropoietic protoporphyria.


Wensink D, Wagenmakers MAEM, Langendonk JG
Expert Rev Clin Pharmacol. 2021 Jan 28.
PMID: 33507118.


In erythropoietic protoporphyria (EPP), an inherited disorder of heme biosynthesis, accumulation of protoporphyrin IX results in acute phototoxicity. EPP patients experience severe burning pain after light exposure, which results in a markedly reduced quality of life (QoL). Afamelanotide is the first effective approved medical treatment for EPP, acting on melanocortin-1 receptors. This article aims to review afamelanotide.