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Papers of the Week

Papers: 23 Jan 2021 - 29 Jan 2021

2021 Jan

Clin Med (Lond)



The challenges of chronic pain and fatigue.


Eccles JA, Davies KA
Clin Med (Lond). 2021 Jan; 21(1):19-27.
PMID: 33479064.


In this review, we explore the challenges of chronic pain and fatigue in clinical practice. Both pain and fatigue are common, troubling and frequently overlapping symptoms, and we describe both the clinical burden and the 'clinical problem'. We explore commonly associated symptoms and possible pathological associations, including variant connective tissue (joint hypermobility), small fibre neuropathy, mast cell activation, dysregulated inflammatory and interoceptive processes, which may inform treatment targets. We suggest a multidisciplinary management approach.