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Papers of the Week


Papers: 23 Jan 2021 - 29 Jan 2021


2021 Jan


Clin Med (Lond)


21


1

The challenges of chronic pain and fatigue.

Authors

Eccles JA, Davies KA
Clin Med (Lond). 2021 Jan; 21(1):19-27.
PMID: 33479064.

Abstract

In this review, we explore the challenges of chronic pain and fatigue in clinical practice. Both pain and fatigue are common, troubling and frequently overlapping symptoms, and we describe both the clinical burden and the 'clinical problem'. We explore commonly associated symptoms and possible pathological associations, including variant connective tissue (joint hypermobility), small fibre neuropathy, mast cell activation, dysregulated inflammatory and interoceptive processes, which may inform treatment targets. We suggest a multidisciplinary management approach.