I am a
Home I AM A Search Login

Papers of the Week

Papers: 2 Jan 2021 - 8 Jan 2021

Animal Studies


2021 Jan 05

J Neuroinflammation



P2X7R-mediated autophagic impairment contributes to central sensitization in a chronic migraine model with recurrent nitroglycerin stimulation in mice.


Jiang L, Zhang Y, Jing F, Long T, Qin G, Zhang D, Chen L, Zhou J
J Neuroinflammation. 2021 Jan 05; 18(1):5.
PMID: 33402188.


Central sensitization is an important pathophysiological mechanism of chronic migraine (CM). According to our previous studies, microglial activation and subsequent inflammation in the trigeminal nucleus caudalis (TNC) contribute to the central sensitization. The P2X7 receptor (P2X7R) is a purinergic receptor expressed in microglia and participates in central sensitization in chronic pain, but its role in CM is unclear. Numerous studies have shown that P2X7R regulates the level of autophagy and that autophagy affects the microglial activation and inflammation. Recently, autophagy has been shown to be involved in neuropathic pain, but there is no information about autophagy in CM. Therefore, the current study investigated the role of P2X7R in CM and its underlying mechanism, focusing on autophagy regulation.