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Papers of the Week

Papers: 5 Dec 2020 - 11 Dec 2020

Human Studies

2020 Dec 08

Eur J Pain

Offset analgesia is reduced on the palm and increases with stimulus duration.


Asplund CL, Kannangath A, Long V J E, Derbyshire SWG
Eur J Pain. 2020 Dec 08.
PMID: 33290593.


A noxious stimulus following a more intense stimulus often feels less painful than continuous noxious stimulation. This effect, known as offset analgesia (OA), may be due to descending inhibitory control, to changes in peripheral neural transmission, or both. The timing and location of noxious thermal stimulation were manipulated to better understand the peripheral and central contributions to OA.