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Papers of the Week

Papers: 7 Nov 2020 - 13 Nov 2020

Human Studies

2020 Nov 10

Eur J Pain

The serotonin receptor 2A (HTR2A) rs6313 variant is associated with higher ongoing pain and signs of central sensitization in neuropathic pain patients.


Sachau J, Bruckmueller H, Gierthmühlen J, Magerl W, May D, Binder A, Forstenpointner J, Koetting J, Maier C, Tölle TR, Treede R-D, Berthele A, Caliebe A, Diesch C, Flor H, Huge V, Maihöfner C, Rehm S, Kersebaum D, Fabig S-C, et al.
Eur J Pain. 2020 Nov 10.
PMID: 33171011.


The serotonin receptor 2A (HTR2A) has been described as an important facilitation mediator of spinal nociceptive processing leading to central sensitization (CS) in animal models of chronic pain. However, whether HTR2A single nucleotide variants (SNVs) modulate neuropathic pain states in patients has not been investigated so far. The aim of this study was to elucidate the potential association of HTR2A variants with sensory abnormalities or ongoing pain in neuropathic pain patients.