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Hydroxychloroquine (HCQ) is a drug that is used for both chemoprophylaxis and treatment of COVID-19. At the moment, HCQ maintain its popularity and tens of thousands of people across the world are still receiving the current drug. After the COVID-19 pandemic, several cutaneous side effects of HCQ are reported. Herein, we reported generalized exanthema after a single dose of using HCQ. A 58-year-old male patient presented with resistant rashes on his upper extremities and neck region. Rashes appeared all over the body along with severe pruritus just a day after receiving a single 200 mg dose of oral hydroxychloroquine for COVID-19 prophylaxis.