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Papers of the Week

Papers: 3 Oct 2020 - 9 Oct 2020

Pharmacology/Drug Development


2020 Sep

Best Pract Res Clin Anaesthesiol



Pharmacological options for the treatment of chronic migraine pain.


Urits I, Gress K, Charipova K, Zamarripa AM, Patel PM, Lassiter G, Jung J W, Kaye AD, Viswanath O
Best Pract Res Clin Anaesthesiol. 2020 Sep; 34(3):383-407.
PMID: 33004155.


Migraine is a debilitating neurological condition with symptoms typically consisting of unilateral and pulsating headache, sensitivity to sensory stimuli, nausea, and vomiting. The World Health Organization (WHO) reports that migraine is the third most prevalent medical disorder and second most disabling neurological condition in the world. There are several options for preventive migraine treatments that include, but are not limited to, anticonvulsants, antidepressants, beta blockers, calcium channel blockers, botulinum toxins, NSAIDs, riboflavin, and magnesium. Patients may also benefit from adjunct nonpharmacological options in the comprehensive prevention of migraines, such as cognitive behavior therapy, relaxation therapies, biofeedback, lifestyle guidance, and education. Preventative therapies are an essential component of the overall approach to the pharmacological treatment of migraine. Comparative studies of newer therapies are needed to help patients receive the best treatment option for chronic migraine pain.