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Papers of the Week

2020 Sep 07

Actas Dermosifiliogr

Multidisciplinary Management of the Adverse Effects of Apremilast.


Daudén Tello E, Alonso Suárez J, Beltrán Catalán E, Blasco Maldonado C, Herrero Manso MC, Jiménez Morales A, Marín-Jiménez I, Martín-Arranz MD, García-Merino A, Porta Etessam J, Rodríguez-Sagrado MA, Rosas Gómez de Salazar J, Trujillo Martín E, Salgado-Boquete L
Actas Dermosifiliogr. 2020 Sep 07.
PMID: 32910923.


We present a series of general and specific recommendations based on pathophysiologic considerations for managing the most common adverse effects of apremilast that lead to treatment discontinuation: diarrhea, nausea, and headache. The recommendations are based on a review of the literature and the experience of a multidisciplinary team of 14 experts including dermatologists, rheumatologists, neurologists, gastroenterologists, pharmacists, and nurses. We propose a series of simple algorithms that include clinical actions and suggestions for pharmacologic treatment. The adverse effects of apremilast can be managed from a multidisciplinary approach. The purpose of optimizing management is to bring clinical benefits to patients.