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Papers of the Week

2020 Aug 24



The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing.


Appelt J, Baranowsky A, Jahn D, Yorgan T, Köhli P, Otto E, Farahani S K, Graef F, Fuchs M, Herrera A, Amling M, Schinke T, Frosch K-H, Duda GN, Tsitsilonis S, Keller J
EBioMedicine. 2020 Aug 24; 59:102970.
PMID: 32853990.


Impaired fracture healing represents an ongoing clinical challenge, as treatment options remain limited. Calcitonin gene-related peptide (CGRP), a neuropeptide targeted by emerging anti-migraine drugs, is also expressed in sensory nerve fibres innervating bone tissue.