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Papers of the Week

2020 Aug 06

Hum Exp Toxicol

Uremic solutes of indoxyl sulfate and -cresol enhance protease-activated receptor-2 expression in vitro and in vivo in keratinocytes.


Kim SJ, Zhang X, Cho SB, Kim CH, Park HC, Moon SJ
Hum Exp Toxicol. 2020 Aug 06:960327120945758.
PMID: 32757783.


Uremic pruritus is common in patients with chronic kidney disease (CKD). The retention of uremic solutes is thought to be associated with uremic pruritus. Meanwhile, activation of protease-activated receptor-2 (PAR-2) has been suggested to play an important role in pruritus. The present study was performed to investigate the effects of uremic solutes on the expression of PAR-2 in the skin.