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Papers of the Week
Uremic solutes of indoxyl sulfate and -cresol enhance protease-activated receptor-2 expression in vitro and in vivo in keratinocytes.
Abstract
Uremic pruritus is common in patients with chronic kidney disease (CKD). The retention of uremic solutes is thought to be associated with uremic pruritus. Meanwhile, activation of protease-activated receptor-2 (PAR-2) has been suggested to play an important role in pruritus. The present study was performed to investigate the effects of uremic solutes on the expression of PAR-2 in the skin.