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Papers of the Week

Papers: 18 Jul 2020 - 24 Jul 2020

Animal Studies, Pharmacology/Drug Development


PLoS One



Anti-GD2 induced allodynia in rats can be reduced by pretreatment with DFMO.


Diccianni MB, Kempińska K, Gangoti JA, Yu AL, Sorkin LS
PLoS One. 2020; 15(7):e0236115.
PMID: 32697811.


Anti-GD2 therapy with dinutuximab is effective in improving the survival of high-risk neuroblastoma patients in remission and after relapse. However, allodynia is the major dose-limiting side effect, hindering its use for neuroblastoma patients at higher doses and for other GD2-expressing malignancies. As polyamines can enhance neuronal sensitization, including development of allodynia and other forms of pathological pain, we hypothesized that polyamine depletion might prove an effective strategy for relief of anti-GD2 induced allodynia.