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Papers of the Week

Papers: 11 Jul 2020 - 17 Jul 2020

Human Studies, Pharmacology/Drug Development


2020 Jul 13


Pain freedom after 2 hours should be the primary outcome in controlled trials treating migraine attacks.


Tfelt-Hansen P, Diener H-C
Cephalalgia. 2020 Jul 13:333102420941827.
PMID: 32660268.


Pain freedom after 2 hours is the recommended primary endpoint by the International Headache Society in randomized trials investigating drug treatment of acute migraine attacks. In order to demonstrate an early effect of a drug, some drug companies, however, have promoted headache relief (improvement from severe or moderate pain to mild or no pain) at earlier time points than 2 hours as outcome parameter.