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Papers of the Week
Sensitization of mGluR-mediated pain behavior via NGF- and A-kinase anchoring protein 5-dependent phosphorylation of TRPV1 under inflammatory conditions.
Abstract
Glutamate and metabotropic glutamate receptors on primary sensory neurons play a pivotal role in modulating pain sensitivity. However, it is unclear how inflammation affects mGluR-mediated nociceptive responses. We therefore investigated the effects of mGluR1/5 agonists on pain-related behavior under persistent inflammation and explored the underlying mechanisms.