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Papers of the Week

Papers: 20 Jun 2020 - 26 Jun 2020

Animal Studies, Pharmacology/Drug Development

2020 Jun 24

Br J Pharmacol

Sensitization of mGluR-mediated pain behavior via NGF- and A-kinase anchoring protein 5-dependent phosphorylation of TRPV1 under inflammatory conditions.


Masuoka T, Yamashita Y, Yoshida J, Nakano K, Tawa M, Nishio M, Ishibashi T
Br J Pharmacol. 2020 Jun 24.
PMID: 32579702.


Glutamate and metabotropic glutamate receptors on primary sensory neurons play a pivotal role in modulating pain sensitivity. However, it is unclear how inflammation affects mGluR-mediated nociceptive responses. We therefore investigated the effects of mGluR1/5 agonists on pain-related behavior under persistent inflammation and explored the underlying mechanisms.