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Papers of the Week

Papers: 13 Jun 2020 - 19 Jun 2020

Animal Studies

2020 Jun 12

J Neuroinflammation



Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain.


Shaqura M, Li L, Mohamed DM, Li X, Treskatsch S, Buhrmann C, Shakibaei M, Beyer A, Mousa SA, Schäfer M
J Neuroinflammation. 2020 Jun 12; 17(1):183.
PMID: 32532285.


Recently, mineralocorticoid receptors (MR) were identified in peripheral nociceptive neurons, and their acute antagonism was responsible for immediate and short-lasting (non-genomic) antinociceptive effects. The same neurons were shown to produce the endogenous ligand aldosterone by the enzyme aldosterone synthase.