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Papers of the Week

Papers: 30 May 2020 - 5 Jun 2020

Human Studies


2020 May 29

J Headache Pain



Microstructural changes in the trigeminal nerve of patients with episodic migraine assessed using magnetic resonance imaging.


Mungoven TJ, Meylakh N, Marciszewski KK, Macefield VG, Macey PM, Henderson LA
J Headache Pain. 2020 May 29; 21(1):59.
PMID: 32471359.


There is histological evidence of microstructural changes in the zygomaticotemporal branch of the trigeminal nerve in migraineurs. This raises the possibility that altered trigeminal nerve properties contribute to migraine pathophysiology. Whilst it is not possible to explore the anatomy of small trigeminal nerve branches it is possible to explore the anatomy of the trigeminal root entry zone using magnetic resonance imaging in humans. The aim of this investigation is to assess the microstructure of the trigeminal nerve in vivo to determine if nerve alterations occur in individuals with episodic migraine.