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Papers of the Week

2020 Mar 01

J Appl Lab Med



Evaluation of a New Skeletal Troponin I Assay in Patients with Idiopathic Inflammatory Myopathies.


Bamberg K, Mehtälä L, Arola O, Laitinen S, Nordling P, Strandberg M, Strandberg N, Paltta J, Mali M, Espinosa-Ortega F, Pirilä L, Lundberg IE, Savukoski T, Pettersson K
J Appl Lab Med. 2020 Mar 01; 5(2):320-331.
PMID: 32445386.


The current biomarkers for diagnosis and monitoring of injured and diseased skeletal muscles, such as creatine kinase (CK), have limited tissue specificity and incapability to differentiate between pathological and physiological changes. Thus, new biomarkers with improved diagnostic accuracy are needed. Our aim was to develop and validate a novel assay for skeletal troponin I (skTnI), and to assess its clinical performance in patients with idiopathic inflammatory myopathies (IIM).