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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Neoline, an active ingredient of the processed aconite root in Goshajinkigan formulation, targets Nav1.7 to ameliorate mechanical hyperalgesia in diabetic mice.

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2020 May 18


J Ethnopharmacol


http://www.ncbi.nlm.nih.gov/pubmed/32439405?dopt=Abstract

Neoline, an active ingredient of the processed aconite root in Goshajinkigan formulation, targets Nav1.7 to ameliorate mechanical hyperalgesia in diabetic mice.

Authors

Neoline, an active ingredient of the processed aconite root in Goshajinkigan formulation, targets Nav1.7 to ameliorate mechanical hyperalgesia in diabetic mice.
Nakatani Y, Negoro K, Yamauchi M, Katasho M, Ishikura K-I, Iwaki A, Tsukada K, Yamaguchi M, Uehara A, Yoshida M, Ishiuchi K'ichiro, Makino T, Kitajima M, Ohsawa M, Amano T
J Ethnopharmacol. 2020 May 18:112963.
PMID: 32439405.

Abstract

Goshajinkigan (GJG), a traditional Japanese Kampo formula, has been shown to exhibit several pharmacological actions, including antinociceptive effects. Processed aconite root (PA), which is considered to be an active ingredient of GJG, has also been demonstrated to have an ameliorative effect on pain, such as diabetic peripheral neuropathic pain. We recently identified neoline as the active ingredient of both GJG and PA that is responsible for its effects against oxaliplatin-induced neuropathic pain in mice.
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