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Burnout is a chronic stress-related syndrome with the three dimensions of exhaustion, cynicism, and inefficacy. Musculoskeletal disorders (MSDs) are defined as a musculoskeletal strain reported by an individual. Burnout is prevalent among Saudi medical students. Many studies have found that burnout is associated with a higher prevalence of MSDs. To the best of our knowledge, there is no study that has assessed the prevalence of burnout among students of health care colleges in Saudi Arabia and its correlation to MSDs and compared the results of each health care college to the other. Hence, this is the aim of this study.