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Papers of the Week

2020 Apr 30

Pharm Res



The Effect of Anesthetic Regimens on Intestinal Absorption of Passively Absorbed Drugs in Rats.


Saphier S, Yacov G, Wenger A, Klausner Z, Rosner A, Goldvaser M, Katalan S
Pharm Res. 2020 Apr 30; 37(5):87.
PMID: 32356106.


Different anesthetic regimens are used during single pass intestinal perfusion (SPIP) experiments for the study of intestinal drug absorption in rats. We examined the ketamine/xylazine anesthetic combination to evaluate its influence on drug absorption compared to older regimens. Additionally, we examined whether supplementary analgesia has any effect on drug absorption and the effect of the different anesthetic regimens on induction time and stress response.