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Papers of the Week
The Effect of Anesthetic Regimens on Intestinal Absorption of Passively Absorbed Drugs in Rats.
Authors
Abstract
Different anesthetic regimens are used during single pass intestinal perfusion (SPIP) experiments for the study of intestinal drug absorption in rats. We examined the ketamine/xylazine anesthetic combination to evaluate its influence on drug absorption compared to older regimens. Additionally, we examined whether supplementary analgesia has any effect on drug absorption and the effect of the different anesthetic regimens on induction time and stress response.