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Papers of the Week

Papers: 25 Apr 2020 - 1 May 2020

Human Studies

2020 Apr 29

Eur J Pain

Activation of the descending pain modulatory system using cuff pressure algometry: Back translation from man to rat.


Cummins TM, Kucharczyk M, Graven-Nielsen T, Bannister K
Eur J Pain. 2020 Apr 29.
PMID: 32350984.


Diffuse noxious inhibitory controls (DNIC) as measured in rat and conditioned pain modulation (CPM), the supposed psychophysical paradigm of DNIC measured in humans, are unique manifestations of an endogenous descending modulatory pathway that is activated by application of a noxious conditioning stimulus. The predictive value of the human CPM processing is crucial when deliberating the translational worth of the two phenomena.