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Papers of the Week

Papers: 4 Apr 2020 - 10 Apr 2020

Pharmacology/Drug Development


2020 Apr 03

Curr Opin Neurol

Gepants, calcitonin-gene-related peptide receptor antagonists: what could be their role in migraine treatment?


Moreno-Ajona D, Pérez-Rodríguez A, Goadsby PJ
Curr Opin Neurol. 2020 Apr 03.
PMID: 32251023.


Migraine is the second leading cause of years lived with disability after back pain. Poor tolerability, contraindications, drug-drug interactions and efficacy limited to a subpopulation make new approaches necessary for the acute and preventive treatment of migraine. The study of the calcitonin-gene-related peptide (CGRP) pathway over the last decades is a good example of translational medicine leading to directed therapies for patients.