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Papers of the Week

Papers: 28 Mar 2020 - 3 Apr 2020

Human Studies


2020 Apr 01

Ann Neurol

Extra-axial inflammatory signal in parameninges in migraine with visual aura.


Hadjikhani N, Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Nahrendorf M, Loggia ML, Moskowitz MA
Ann Neurol. 2020 Apr 01.
PMID: 32239542.


Cortical spreading depression (CSD) underlies the neurobiology of migraine with aura (MWA). Animal studies reveal networks of microvessels linking brain-meninges-bone marrow. CSD activates the trigeminovascular system, evoking a meningeal inflammatory response. Accordingly, this study examines the upregulation of an inflammatory marker in extra-axial tissues in migraine with visual aura.