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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Extra-axial inflammatory signal in parameninges in migraine with visual aura.

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Papers: 28 Mar 2020 - 3 Apr 2020


Human Studies

PAIN TYPE:
Migraine/Headache


2020 Apr 01


Ann Neurol


http://www.ncbi.nlm.nih.gov/pubmed/32239542?dopt=Abstract

Extra-axial inflammatory signal in parameninges in migraine with visual aura.

Authors

Extra-axial inflammatory signal in parameninges in migraine with visual aura.
Hadjikhani N, Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Nahrendorf M, Loggia ML, Moskowitz MA
Ann Neurol. 2020 Apr 01.
PMID: 32239542.

Abstract

Cortical spreading depression (CSD) underlies the neurobiology of migraine with aura (MWA). Animal studies reveal networks of microvessels linking brain-meninges-bone marrow. CSD activates the trigeminovascular system, evoking a meningeal inflammatory response. Accordingly, this study examines the upregulation of an inflammatory marker in extra-axial tissues in migraine with visual aura.
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