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Papers of the Week

Papers: 14 Mar 2020 - 20 Mar 2020

Animal Studies

2020 Mar 13


Transcribed ultraconserved noncoding RNA uc.153 is a new player in neuropathic pain.


Zhang C, Peng Y, Wang Y, Xu H, Zhou X
Pain. 2020 Mar 13.
PMID: 32187117.


Transcribed ultraconserved regions (T-UCRs) are a novel class of long noncoding RNAs (lncRNAs) and are completely conserved in humans, rats, and mice. T-UCRs have been implicated in diverse biological processes; however, very little is currently known about their role in pain modulation. Here, we found that the level of the spinal T-UCR uc.153 was significantly increased in a mouse model of sciatic nerve chronic constriction injury (CCI)-induced chronic neuropathic pain. The knockdown of spinal uc.153 prevented and reversed CCI-induced pain behaviours and spinal neuronal sensitization. In contrast, the overexpression of spinal uc.153 produced pain behaviours and neuronal sensitization in naive mice. Moreover, we found that uc.153 participates in the regulation of neuropathic pain by negatively modulating the processing of pre-miR-182-5p. Collectively, our findings reveal an important role for uc.153 in pain modulation and provide a novel drug target for neuropathic pain therapy.